University of Macau
Ceremony for the Conferment of Honorary Degrees and UM's Doctor honoris causa Lecture 澳門大學榮譽學位頒授典禮暨榮譽博士講座

 榮譽博士講座: 

從次世代物種特異性環保型抗生素到生命起源的聯想

2009年諾貝爾化學獎得主

阿達·尤納斯教授主講 

UM’s Doctor honoris causa Lecture:

Next Generation Species Specific Eco Friendly Antibiotics and Thoughts About Origin of Life

by

Prof. Ada Yonath

2009 Nobel Prize winner in Chemistry

 

Abstract

Resistance to antibiotics is a severe problem in contemporary medicine. Many antibiotics inhibit protein biosynthesis by hampering the ribosome function. Structures of bacterial ribosomes in complex with these antibiotics illuminated common pathways of antibiotics inhibitory action, but not the species-specific diversity in infectious-diseases susceptibility. Recent structural studies on ribosome from a multi-resistant pathogenic bacterium and careful comparisons to ribosomes from non-pathogenic bacteria revealed novel structural motifs, essential to cellular protein biosynthesis but are not located in the primary ribosomal active sites, hence no mechanism for mutations leading to resistance of these sites is currently known. These findings led to the design of antibiotics with desired properties that can be optimized in terms of their chemical properties, toxicity, penetration, species-specificity, thus preserving the microbiome. They can also be optimized in terms of bio-degradability, thus reducing the ecological hazards caused by the spread of the current antibiotics’ non-degradable metabolites.

In all modern ribosomes, the internal active site, where peptide bonds are formed, seems to be a remnant of a prebiotic bonding apparatus, which evolved and optimized together with the introduction and development of the genetic code, its products, the proteins, and the ribosomes.  Interestingly, some of the ribosomal RNA insertions identified in eukaryotic ribosomes overlap insertions detected in ribosomes of pathogenic bacteria. Hence, raising the question: is pathogenicity a missing link between eubacteria and eukaryotes?     

 

日期:二零一
時間:
午九時三十分十一
地點:澳門大學劉少榮大樓 (E4) 劉佐德伉儷演講廳
截止日期:二零一
三十一
語言:英語

如有垂詢,請與
小姐聯繫。電話:(853) 8822 4230,電郵:fhs@umac.mo

**請提前十五分鐘到場**

**來賓可以使用位於中央教學樓P5公眾停車場**


Date: 9th June 2018
Time: 9:30 – 11:00
Venue: Mr. and Mrs. Lau Chor Tak Lecture Threatre, Anthony Lau Building (E4), University of Macau
Language: English 
Deadline for Registration: 31st May 2018
For enquiry, please contact Ms. Vivienne Fong at Tel: (853) 8822 4230, Email: fhs@umac.mo

 **Kindly arrive at the venue 15 minutes in advance**

 **Guests can park at the P5 carpark located at the basement of Central Teaching Building.**

 

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